Mitochondrial uncoupling and thermogenesis
نویسندگان
چکیده
منابع مشابه
Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis
BACKGROUND Mild cold exposure and overfeeding are known to elevate energy expenditure in mammals, including humans. This process is called adaptive thermogenesis. In small animals, adaptive thermogenesis is mainly caused by mitochondrial uncoupling in brown adipose tissue and regulated via the sympathetic nervous system. In humans, skeletal muscle is a candidate tissue, known to account for a l...
متن کاملOxidative stress, thermogenesis and evolution of uncoupling proteins
The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.
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The biogenesis of mitochondria requires products of the nuclear and mitochondrial genomes. Recent studies of adaptive thermogenesis have shown how mitochondrial proliferation and respiratory activity in brown fat and skeletal muscle are directed by the transcriptional coactivator PGC-1.
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The aim of this review is to provide an overview of current knowledge on the three mammalian uncoupling proteins, UCP-1, UCP-2, and UCP-3. Heart Metab. 2010;48:32–34.
متن کاملTheoretical Model and Characteristics of Mitochondrial Thermogenesis
Based on the first law of thermodynamics and thermal diffusion equation, the thermal physical model of thermogenesis for brown adipocyte is deduced. The model settles the long-standing questioning about the ability of raising cellular temperature by endogenous thermogenesis, and explains the thermogenic characteristics of brown adipocyte. The model and calculations also suggest that the number ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2014
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2014.05.339